How does psoriasis affect the cardiovascular system?
How does psoriasis affect the cardiovascular system?
Psoriasis causes inflammation on your skin and inside your body. Long-lasting inflammation inside your body may affect your heart and blood vessels, putting you at greater risk of developing heart disease or having a stroke.
How does psoriatic arthritis affect the cardiovascular system?
Known as plaques, these fatty deposits narrow arteries, raising blood pressure and reducing the flow of blood to the heart and other organs. Some unstable plaques can rupture, triggering a clot that may cause a heart attack or stroke.
What is the pathogenesis of cardiovascular disease?
Chronic psychosocial stress plays a key role in the pathogenesis of vascular diseases (both cardiovascular diseases and disorders of micro vascular circulation), which when severe in intensity, accelerates the inflammation, increasing morbidity and mortality especially, when multiple conditions are present together …
Can psoriasis cause AFIB?
Atrial fibrillation risk was 22% higher in people with mild psoriasis and 51% higher in those with moderate-to-severe psoriasis.
Can psoriatic arthritis cause atrial fibrillation?
Patients with Psoriatic Arthritis at Greater Risk for Developing Arrhythmias. Analysis of a population-based cohort indicates that patients with psoriasis and psoriatic arthritis face an elevated risk of developing heart arrhythmias such as atrial fibrillation.
What is the last step in regarding pathogenesis of cardiovascular disease?
The final result of this process is formation of the first typical atherosclerotic lesion, ie, the fatty streak, in which foam cells are present in the subendothelial space. Other types of leukocytes, such as lymphocytes and mast cells, also accumulate in the subendothelial space.
Does psoriasis increase the risk of cardiovascular disease?
Stern R.S., Huibregtse A. Very severe psoriasis is associated with increased noncardiovascular mortality but not with increased cardiovascular risk. J. Investig. Dermatol. 2011;131:1159–1166. doi: 10.1038/jid.2010.399.
What is the pathophysiology of psoriasis?
Psoriasis is a chronic, complex autoimmune disease characterized by erythematous, scaly patches over extensor aspects of skin and is associated with joint involvement in about one-third of patients.
What is the pathophysiology of psoriasis on chromosome 6p21?
PSORS1 is located on chromosome 6p21 within the major histocompatibility complex (MHC), which is specifically in the class I telomeric region of HLA-B, and spans an approximately 220 kb-long segment and corresponds to HLA-Cw6 (C*06:02). HLA-Cw6 is strongly linked to early and acute onset psoriasis [90,91].
What is the role of epigenetics in the pathophysiology of psoriasis?
A role for epigenetics in psoriasis: Methylated cytosine-guanine sites differentiate lesional from nonlesional skin and from normal skin. J. Investig. Dermatol. 2012;132:506–508. doi: 10.1038/jid.2011.364.