How effective is Yondelis?
How effective is Yondelis?
The overall 5-year relative survival rate is approximately 65% for patients with soft-tissue sarcoma. However, the 5-year relative survival is 15% for patients with distant metastatic soft-tissue sarcoma, and 22% for patients with regional metastatic disease (spread to regional lymph nodes).
What does trabectedin do?
Trabectedin injection is used to treat liposarcoma (a cancer that begins in fat cells) or leiomyosarcoma (a cancer that begins in smooth muscle tissue) that has spread to other parts of the body and cannot be treated with surgery in people who have already been treated with certain chemotherapy medications.
What is Yondelis used for?
Trabectedin is a chemotherapy drug and is also known by its brand name, Yondelis. It is a treatment for: advanced soft tissue sarcoma (for people who have already had treatment with, or are unable to have ifosfamide and an anthracycline chemotherapy such as doxorubicin)
How is Yondelis administered?
YONDELIS ® is administered as an intravenous infusion over 24 hours through a central venous line every 21 days (3 weeks), until disease progression or unacceptable toxicity. YONDELIS ® may be administered to inpatients or outpatients, via stationary or ambulatory pump, at the physician’s discretion.
Can trabectedin shrink tumors?
Interestingly, in the in vivo setting, trabectedin still showed anti-tumour activity (Germano et al, 2013). The results clearly indicated that the macrophage-targeted effect was sufficient to significantly reduce neoplastic growth, under conditions where tumour cells were unresponsive to the drug.
Do you lose your hair with trabectedin?
Your hair may thin out, though it is unlikely you will lose all of the hair on your head. Hair loss normally starts after your first or second cycle of chemotherapy. It is almost always temporary, and the hair will continue to grow after you finish your treatment.
What is trabectedin made from?
Trabectedin is natural product derived from the Caribbean sea squirt which has antineoplastic activity and is used to treat soft tissue sarcoma.
What is soft cell sarcoma?
Soft tissue sarcoma is a rare type of cancer that begins in the tissues that connect, support and surround other body structures. This includes muscle, fat, blood vessels, nerves, tendons and the lining of your joints. More than 50 subtypes of soft tissue sarcoma exist.
What type of chemo is trabectedin?
Drug Type: Trabectedin is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug.
How long does trabectedin stay in your system?
This includes a decrease in: • Red blood cells, which carry oxygen in your body to help give you energy • White blood cells, which fight infection in your body • Platelets, which help clot the blood to stop bleeding This may happen 7 to 14 days after the drug is given and then blood counts should return to normal.
Is trabectedin approved by FDA?
On October 23, the Food and Drug Administration (FDA) approved trabectedin (Yondelis®) for the treatment of two subtypes of soft tissue sarcomas: liposarcoma and leiomyosarcoma.
Can you survive soft tissue sarcoma?
Overall, approximately 65% of adults treated for soft tissue sarcoma are alive five years after treatment. That survival rate increases to 81% for people whose cancer is diagnosed and treated before it spreads.