Is XMRV A retrovirus?
Is XMRV A retrovirus?
This supported the conclusion that XMRV was a retrovirus that was infecting human cells, and not likely a polymerase chain reaction (PCR) artifact (however, as it was later determined that the XMRV-infected human cells represented contamination with an infected human PC cell line,27,28 as will be discussed below).
What type of virus is XMRV?
Xenotropic murine leukemia virus-related virus (XMRV) is a γ retrovirus that has been associated with chronic fatigue syndrome (CFS) and prostate cancer. The search for viral causes of these syndromes was reignited by the finding that RNase L activity was low in hereditary prostate cancer and some CFS patients.
What does XMRV cause?
XMRV is a candidate infectious agent for causing prostate cancer.
Can XMRV infect humans?
XMRV Can Infect Human Cells Although XMRV was originally described as infecting human prostate stromal cells (Urisman et al., 2006), in vitro assays show that the virus can infect and replicate in various human, feral mouse, mink, monkey, and bovine cell lines (Stieler et al., 2010).
What does XMRV stand for?
XMRV stands for xenotropic murine leukemia virus-related virus. This study is being reported in the same issue of Science as another study of XMRV (Knox et al.) that finds a lack of association between the virus and CFS even in the same patients from a 2009 study.
Is XMulV a retrovirus?
XMulV is a gamma retrovirus. It was previously believed to be a noninfectious retrovirus, but currently it has proven to be an infectious human virus2, 3, 4: the virus was detected in the tissue of patients with chronic fatigue syndrome.
What is the treatment for XMRV?
Because XMRV is a retrovirus, it might be susceptible to antiviral drugs that are licensed for the treatment of AIDS. AZT (azidothymidine) was previously found to block XMRV replication. A screen of forty-five compounds reveals that XMRV replication is inhibited by raltegravir and three other drugs.
How is XMRV transmitted?
The detection of XMRV fragments in the respiratory tract (Fischer et al., 2010) suggests that the virus may be transmitted by saliva, although RNA concentrations were low. Transmission through saliva, mainly by biting, has been reported for most retrovirus genera, including ecotropic MLV’s (Portis et al., 1987).
How do you get tested for XMRV?
Currently, there are no commercially available FDA approved/licensed tests for detection of XMRV or other MLV-related human retroviruses. Standards for the diagnosis of XMRV or MLV-related retrovirus infection based on laboratory test methods have not been established.
What does Xmrv stand for?