What bacteria does linezolid cover?
What bacteria does linezolid cover?
Linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA).
Does linezolid cover strep pyogenes?
Linezolid is a bacterial protein synthesis inhibitor that has been shown to provide excellent coverage of S. pyogenes including toxin inhibition in vitro, but clinical evidence is lacking. We compared outcomes of patients treated with linezolid versus clindamycin for serious S. pyogenes infections.
Does linezolid cover strep Viridans?
Linezolid is a potent new antimicrobial uniformly active against methicillin- and teicoplanin-resistant staphylococci, glycopeptide-resistant enterococci, penicillin- and erythromycin-resistant pneumococci and viridans streptococci, and erythromycin-resistant S.
Is linezolid effective against Pseudomonas?
Linezolid is not active against Acinetobacter spp, Escherichia coli,Klebsiella pneumoniae, Proteus penneri, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia (72,116,136). In addition, linezolid displays minimal activity against Haemophilus influenzae and Neisseria gonorrhea, with MIC90s of 16 µg/ml (72,130).
Does linezolid cover E coli?
While free linezolid or linezolid loaded silica xerogel is not active against E. coli and P. aeruginosa, a linezolid-loaded silica xerogel capped with ε-poly-L-lysine shows high bactericidal activity for both bacteria.
Does linezolid cover Gram-positive rods?
Linezolid is a synthetic oxazolidinone antimicrobial drug. It is indicated for gram-positive infections and approved for the treatment of bacterial pneumonia, skin and skin structure infections, and vancomycin-resistant enterococcal (VRE) infections, including infections complicated by bacteremia.
Does linezolid cover Enterococcus faecalis?
Linezolid is the first oxalidinone antibiotic approved for clinical use. It has activity against sensitive and resistant strains of Staphylococcus aureus and vancomycin-sensitive and vancomycin-resistant strains of E. faecalis and Enterococcus faecium, as well as against Streptococcus pneumoniae.
Does linezolid cover MSSA?
Linezolid has in vitro activity against both MSSA and MRSA. Clinical activity has been confirmed in many types of infections including nosocomial pneumonia,9,10 ventilator-associated pneumonia,11 complicated skin and soft tissue infections,12 and MRSA infections.
Does linezolid have atypical coverage?
Linezolid possesses activity against ”atypical organisms”, including Legionella pneumophila, Mycoplasma pneumoniae, and Chlamydia pneumoniae, and has good activity against many Gram-positive anaerobes.
When do you use vancomycin vs linezolid?
Linezolid seems to be more effective than vancomycin for treating people with SSTIs, including SSTIs caused by MRSA. The available evidence is at high risk of bias and is based on studies that were supported by the pharmaceutical company that makes linezolid.
Does Zyvox treat Enterococcus?
Linezolid (Zyvox), a novel antimicrobial agent, has been approved by the U.S. Food and Drug Administration (FDA) primarily to fight resistant gram-positive cocci, such as vancomycin-resistant enterococcus, methicillin-resistant S. aureus, and penicillin-resistant pneumococci.
What is the best antibiotic for Enterococcus?
Ampicillin is the drug of choice for monotherapy of susceptible E faecalis infection. For most isolates, the MIC of ampicillin is 2- to 4-fold lower than that of penicillin. For rare strains that are resistant to ampicillin because of beta-lactamase production, ampicillin plus sulbactam may be used.