What bone issues cause elevated alkaline phosphatase?
What bone issues cause elevated alkaline phosphatase?
Bone pathology causes of elevated alkaline phosphatase include Paget’s disease, hyperparathyroidism, osteomalacia, metastatic bone disease and a recent fracture.
What happens if alkaline phosphatase is high?
Higher-than-normal levels of ALP in your blood may indicate a health concern with your liver or gallbladder. This could include a blockage in your bile ducts, gallstones, cirrhosis, liver cancer, and some forms of hepatitis.
What does alkaline phosphatase do in bone?
ALP increases inorganic phosphate local rates and facilitates mineralization as well as reduces the extracellular pyrophosphate concentration, an inhibitor of mineral formation.
What is the treatment for high alkaline phosphatase?
Reduction in serum alkaline phosphatase levels by treatment with active vitamin D (alphacalcidol) in primary and secondary hyperparathyroidism and in euparathyroid individuals.
Can arthritis cause high alkaline phosphatase?
Increased concentration of serum alkaline phosphatase (ALP) is a common feature in rheumatoid arthritis (RA), although its origin remains unclear.
Can osteoporosis cause high alkaline phosphatase?
Osteoporosis is a metabolic disease that raises alkaline phosphatase (ALP) levels. ALP, a homodimeric enzyme of 86 kilodaltons, plays a vital role in metabolism within the liver and bone. Clinicians use bisphosphonates to reduce the level of ALP, thus preventing a further decrease in bone mineral density.
Can vitamin D deficiency cause elevated alkaline phosphatase?
Elevated serum alkaline phosphatase (ALP) level is an essential marker for the diagnosis of vitamin D deficiency (1). Some cases of vitamin D deficiency are diagnosed accidentally on the basis of elevated ALP levels.
Can stress cause high alkaline phosphatase?
The present study shows that ALP mRNA and activity were significantly increased by ER stress treatment of human primary VSMCs in vitro and that this was ATF4-dependent.
Can alkaline phosphatase be elevated in osteoporosis?
Biver, et al. has also showed raised levels of bone alkaline phosphatase in osteoporotic patients compared to normal, and these high levels may be associated with prevalent vertebral fractures.
Can inflammation cause high alkaline phosphatase?
Thus, inflammatory processes may contribute to increase serum ALP concentration in the presence of vessel inflammation.
How do you lower bone alkaline phosphatase?
Clinicians use bisphosphonates to reduce the level of ALP, thus preventing a further decrease in bone mineral density. In addition, bisphosphonates also lower the level of ALP in Paget disease15.
What is a critical level of alkaline phosphatase?
Interpretation
By U/L | By μkat/L | |
---|---|---|
Adults | 33 to 96 U/L | 0.55 to 1.6 μkat/L |
Children | Under 350 U/L | Under 5.8 μkat/L |
Pregnacy (first trimester) | 17 to 88 U/L | 0.28 to 1.47 μkat/L |
Pregnacy (second trimester) | 25 to 126 U/L | 0.42 to 2.1 μkat/L |