What drugs contain interferon beta?
What drugs contain interferon beta?
Beta interferons are disease modifying therapies (DMTs) for relapsing MS and in some cases secondary progressive MS. Their brand names are Avonex, Betaferon, Extavia, Plegridy, Rebif and they are all taken as injections.
What is interferon beta used for?
Interferon beta-1b injection is used to reduce episodes of symptoms in patients with relapsing-remitting (course of disease where symptoms flare up from time to time) of multiple sclerosis (MS, a disease in which the nerves do not function properly and patients may experience weakness, numbness, loss of muscle …
How is interferon beta produced?
IFN β-1a is produced in mammalian cells (Chinese hamster ovary) using a natural human gene sequence and is glycosylated, while IFN β-1b is produced in Escherichia coli cells using a modified human gene sequence containing a genetically engineered cysteine-to-serine substitution at position 17.
Where is interferon beta produced?
Interferon beta (IFN-β) is a cytokine produced by innate immune cells, including macrophages and dendritic cells, as well as non-immune cells, such as fibroblasts and epithelial cells (Ivashkiv and Donlin, 2014).
How much does interferon beta-1a cost?
Table 44Cost Table of RRMS Treatments
Drug/Comparator | Strength | Annual Drug Cost ($) |
---|---|---|
Interferon beta-1a (Rebif) | 22 mcg (6 MIU) | $20,210 |
Interferon beta-1a (Rebif) | 44 mcg (12 MIU) | $24,604 |
Interferon beta-1b (Betaseron) | 0.3 mg | $20,130 |
Interferon beta-1b (Extavia) | 0.3 mg | $18,183 |
Is Tysabri a beta interferon?
Are Rebif and Tysabri the Same Thing? Rebif (interferon beta-1a) Injection and Tysabri (natalizumab) are used to treat relapsing multiple sclerosis (MS). Tysabri is also used to treat moderate to severe Crohn’s disease in adults.
What is the difference between interferon alpha and beta?
IFN-alpha is produced in the leukocytes infected with virus, while IFN-beta is from fibroblasts infected with virus. IFN-gamma is induced by the stimulation of sensitized lymphocytes with antigen or non-sensitized lymphocytes with mitogens.
Is interferon still used?
As well as occurring naturally in the body, interferon is also used as a treatment for various health disorders, including multiple sclerosis (MS), some types of cancer, and hepatitis C.
Does beta interferon suppress the immune system?
Interferon proteins are normally considered virus-fighters, but scientists have found evidence that one of them, interferon beta, has an immune-suppressing effect that can help some viruses establish persistent infections.
Is interferon an antiviral?
The interferons (IFNs) are glycoproteins with strong antiviral activities that represent one of the first lines of host defense against invading pathogens. These proteins are classified into three groups, Type I, II and III IFNs, based on the structure of their receptors on the cell surface.
What is generic for Rebif?
Generic Name: interferon beta-1a (albumin) This medication is used to treat multiple sclerosis (MS). Interferon is not a cure for MS, but it may help to slow disease worsening and decrease flare-ups of symptoms (such as balance problems, numbness, or weakness).
How much does interferon treatment cost?
The total cost of the IFN treatment regimen was estimated to range between US$1,120 and US$1,962 and the total cost of the Peg-IFN treatment regimen between US$2,156 and US$5,887 ( Table 3).