What is a Phasix mesh?

What is a Phasix mesh?

Phasix™ Mesh is a knitted monofilament mesh scaffold made of Poly-4-hydroxybutyrate (P4HB), a biologically derived, fully resorbable material. • It allows for the assembly of new collagen around a macroporous scaffold, which resorbs slowly over time and is replaced with new host collagen.

What is Phasix mesh made from?

Phasix™ (C. R. Bard, Inc./Davol Inc., Warwick, RI) is a macroporous, fully absorbable mesh device that consists of knitted absorbable monofilament poly-4-hydroxybutyrate fibers. Strattice™ (LifeCell Corp., Branchburg, NJ) is a biologically derived prosthetic comprised of acellular, non-cross-linked porcine dermis.

How long does Phasix mesh last?

Preclinical implantation studies indicate that Phasix™ Mesh retains approximately 70% of its original strength at 12 weeks [23]. Absorption of the mesh material will be essentially complete in 12–18 months [24].

Is Phasix mesh absorbable?

Phasix meshes are absorbable within 12–18 months17, and a follow up of at least 18 months can give us an idea of what happens once the prosthesis has been completely resorbed.

What is biologic mesh?

Biological Mesh. Biological grafts are derived from human, bovine, and porcine tissue that has been decellularized to leave a collagen matrix. This structure acts as a regenerative framework that supports remodeling and new collagen deposition.

What mesh is used for hernia repair?

Polypropylene mesh is used for most hernia repairs. Polypropylene mesh is the most widely-used type of mesh for hernia repair. Other leading mesh materials include polyester and ePTFE — a fluorocarbon polymer best known by the brand name Teflon. Manufacturers may combine these materials with others including titanium.

How long does it take for hernia mesh to integrate?

The mesh can be attached via tissue glues, tacks, staples, or sutures. It is also important to note that these attachment methods are also used in other types of surgeries. The mesh needs to remain in place until tissue integration is complete. Complete integration usually happens around 2-3 weeks after surgery [10].

Why is synthetic mesh avoided in infection?

There is a consensus that synthetic mesh must be avoided in infected operations. The alternatives to using synthetic mesh, such as component separation techniques and biologic mesh, present disappointing results with expressive wound infection and hernia recurrence rates.

Is biologic mesh safe?

In an expert consensus guided by systematic review on ventral hernia management, a statement is made that biological meshes have been safely utilized in abdominal wall reconstruction with few mesh explantations [46]. However, their role still needs to be defined.

What happens to the mesh after surgery?

Non-absorbable mesh will remain in the body indefinitely and is considered a permanent implant. It is used to provide permanent reinforcement to the repaired hernia. Absorbable mesh will degrade and lose strength over time. It is not intended to provide long-term reinforcement to the repair site.

What are hernia mesh complications?

Hernia mesh complications include adhesion, bowel obstruction or perforation, infection, rejection and migration. After hernia mesh surgery, patients have reported symptoms of pain, mesh failure and hernia recurrence. Hernia mesh problems can occur immediately after surgery or years later.

What are symptoms of mesh problems?

Symptoms of mesh erosion into the bladder/urethra include painful voiding, urinary frequency, urgency, hematuria, recurrent urinary tract infection, urinary calculi and urinary fistula.