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What is the name for the immunohistochemical marker for prostate disease?

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What is the name for the immunohistochemical marker for prostate disease?

Alpha-methylacyl-CoA racemase: a variably sensitive immunohistochemical marker for the diagnosis of small prostate cancer foci on needle biopsy.

How do you know if prostate cancer is metastatic?

You’re most likely to find out the cancer has spread if your doctor tests your blood and finds high levels of prostate-specific antigen, or PSA. They might also find it with a digital rectal exam or on an X-ray or other test. If you do have symptoms, they often include trouble peeing or blood in your urine.

What is prostate triple stain?

This test uses a combination of several antibodies (applied to a single slide) that differentially stain for basal cells and neoplastic cells in the prostate: P504S stains prostate adenocarcinoma, whereas p63 and the high molecular weight cytokeratins stain benign prostate basal epithelial tissue.

Which marker is used for detection prostatic cancer?

Prostate specific antigen (PSA), which has high organ specificity, is an excellent tumor marker that has played a significant role in the diagnosis and treatment of prostate cancer.

How do doctors know if prostate cancer has spread?

A lymph node biopsy may be done if the doctor thinks the cancer might have spread from the prostate to nearby lymph nodes. CT scan: This is sometimes called a “CAT scan.” It’ uses x-rays to make detailed pictures of the body. A CT scan can show whether the cancer has spread outside the prostate.

What does AMACR positive mean?

Alpha-methylacyl-CoA-racemase (AMACR) is a recently discovered tumor marker whose expression is significantly upregulated in prostate cancer.

What is PIN4 cocktail?

One widely used antibody cocktail is commonly referred to as “PIN4”; it consists of a combination of 1 or 2 antibodies against high-molecular-weight (HMW) keratin plus antibodies to p63 and p504s (also known as AMACR enzyme). The usefulness of this cocktail has been proven beyond doubt in the literature.

What are the different tumor markers?

There are many different types of tumour markers, including:

  • alpha-fetoprotein (AFP)
  • cancer antigen 125 (CA125)
  • cancer antigen 15-3 (CA15-3)
  • carbohydrate antigen 19-9 (CA19-9)
  • carcinoembryonic antigen (CEA)
  • human chorionic gonadotropin (hCG or beta-hCG)
  • prostate-specific antigen (PSA)

What does pattern 4 mean in a prostate biopsy?

Gleason score 3+4=7 prostate cancer with minimal quantity of Gleason pattern 4 on needle biopsy is associated with low-risk tumor in radical prostatectomy specimen.