Questions

What is the purpose of adding sodium thiosulfate?

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What is the purpose of adding sodium thiosulfate?

Sodium thiosulfate (STS) is an industrial chemical which also has a long medical history. It was originally used as an intravenous medication for metal poisoning. It has since been approved for the treatment of certain rare medical conditions. These include cyanide poisoning, calciphylaxis, and cisplatin toxicity.

Is sodium thiosulfate toxic to the environment?

Sodium thiosulphate is not expected to absorb to soil or sediment because of its dissociation properties and high water solubility. Sodium thiosulphate is of low toxicity concern to aquatic organisms.

What can you do with sodium thiosulfate?

Sodium thiosulfate may be used to lessen some of the side effects of cisplatin (a cancer medicine). It is also used with another medicine in the emergency treatment of cyanide poisoning. Sodium thiosulfate is to be administered only by or under the immediate supervision of your doctor.

What does thiosulfate react with?

hydrochloric acid
Sodium thiosulfate solution is a body tissue irritant. The reaction of sodium thiosulfate and hydrochloric acid generates sulfur dioxide gas, which is a skin and eye irritant.

How long does it take for sodium thiosulfate to work?

2 weeks
Symptomatic relief and clinical improvement may occur within 2 weeks.

Does sodium thiosulfate affect pH?

Overdosing with sodium thiosulfate could also result in depressed pH and dissolved oxygen (Ryon et al., 2002) , by which affect the sample toxicity.

Which exposure is considered the biggest risk when using sodium thiosulphate?

Inhalation: May cause upper respiratory tract and mucous membrane irritation. Ingestion: Sodium Thiosulfate is an agent with a low order of toxicity. Ingestion of large doses may cause gastrointestinal irritation disturbances with nausea, vomiting, addominal cramping, diarrhea, metabolic acidosis, and hypernatremia.

Is sodium thiosulfate poisonous?

Sodium thiosulfate is a sulfur donor that promotes the conversion of cyanide to the less toxic thiocyanate by the sulfur transferase enzyme rhodanese. Unlike nitrites, thiosulfate is essentially nontoxic and may be given empirically in suspected cyanide poisoning.

What are the risks of sodium thiosulfate?

Eye: May cause mild eye irritation.

  • Skin: May cause skin irritation.
  • Ingestion: Ingestion of large amounts may cause gastrointestinal irritation.
  • Inhalation: May cause respiratory tract irritation. Low hazard for usual industrial handling.
  • Chronic: No information found.

    • How quickly does sodium thiosulfate work?

    Symptomatic relief and clinical improvement may occur within 2 weeks.

    Is sodium thiosulfate corrosive?

    Thiosulfate salts have been known to be dangerous corrosion promoters for over 30 y, when present under typical service conditions.

    How much sodium thiosulfate do I need?

    A range of approximately 2 to 7 parts sodium thiosulfate to neutralize one part chlorine is generally suggested, for example to neutralize 1 liter of a 200 ppm chlorine solution, approximately 0.4 – 1.4 grams of sodium thiosulfate would be required or to neutralize one gallon of a 200 ppm chlorine solution.