What is the significance of variant histology in urothelial carcinoma?

What is the significance of variant histology in urothelial carcinoma?

Patient summary: It is important to recognise histological variants of urothelial carcinoma as they indicate aggressive disease. When compared with patients with pure urothelial carcinoma of the same disease stage, survival does not appear to be significantly worse.

Can high grade urothelial carcinoma be cured?

High-grade T1 (T1HG) bladder cancer (BCa) has a very high likelihood of disease recurrence and progression to muscle invasion. Radical cystectomy is considered the best chance at cure, albeit with a high risk of morbidity, and is overtreatment for some patients.

What is the treatment for high grade urothelial carcinoma?

If the cancer is high grade, if many tumors are present, or if the tumor is very large when it’s first found, radical cystectomy may be recommended. For people who aren’t healthy enough for a cystectomy, radiation therapy (often along with chemo) might be an option, but the chances for cure are not as good.

What is negative for high grade urothelial carcinoma?

Definition of Negative for High-Grade Urothelial Carcinoma (NHGUC) A sample of urine, either voided or instrumented (including washing specimens), may be categorized as NHGUC if it is diagnostically adequate (see Chap. 2, Adequacy) and lacks any cytomorphologic findings shown to be significantly associated with HGUC.

What is high grade urothelial carcinoma with squamous differentiation?

Urothelial carcinoma with squamous differentiation (UCSD) is a variation of urothelial cell carcinoma which is associated with advanced tumor stage. When occurring in relation to bladder cancer, around 60-70% of the cases occur in those with muscle-invasive bladder cancer (MIBC) 1.

What is variant histology?

Variant histology includes any bladder malignancy other than pure urothelial cancer, such as UC with aberrant differentiation as well as pure non-UC resulting from metaplasia (5).

How fast does urothelial carcinoma grow?

Papillary urothelial carcinoma is often slow growing , and it can be easier to treat than other types of bladder cancer. The prognosis is generally good. A person who receives a diagnosis of bladder cancer in the earliest stage, before it has started to spread, has a 95% chance of living for at least another 5 years.